IMMUNE CORRELATES OF PROTECTION AND RECOVERY: HEPATITIS C VIRUS

 Objectives

• Identify current biomarkers used in the evaluation of therapeutics and preventive interventions for hepatitis C virus (HCV) infections
• Explore immune response parameters in the control and cure of HCV infections
• Determine areas of need, opportunity, and viable approaches to developing clinical assessment tools to evaluate HCV therapies
• Identify applicable tools, technologies, and strategies to evaluate response to HCV treatments

Overview of the Hepatitis C Virus:  Natural History and Current Therapeutic Regimens
Karen L. Lindsay, M.D., University of Southern California

Intrahepatic Immune Responses Against Hepatitis C Virus
Margaret J. Koziel, M.D., Beth Israel Deaconess Medical Center

Role of the Cellular Immune Response During Recovery From Hepatitis C Virus Infection
Barbara Rehermann, M.D., National Institute of Diabetes and Digestive and Kidney Diseases

Hepatitis C Virus Vaccine Design and Surrogate Markers of Protective Immunity
Christopher M. Walker, M.D., Ohio State University College of Medicine and Public Health

Immune-Based Strategies and Therapeutic Vaccines
Gregory R. Reyes, M.D., Ph.D., Schering-Plough Research Institute

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