NEUROSCIENCES II - BIOMARKERS FOR ALCOHOL AND DRUG ABUSE

Objectives

• Evaluate the use of imaging technologies for the assessment of receptor changes in the CNS and the evaluation of subjects in clinical trials based on receptor responses
• Gain an appreciation of the state of the art in using brain imaging techniques as biomarkers of addiction
• Understand the advantages of computerized cognitive testing in clinical trials
• Achieve an appreciation of antecedent markers of vulnerability to alcohol use and markers of current use
• Consider the application of statistical modeling issues involved in integration of multiple domains into an index biomarker

Agenda

Neuroimaging Markers

Opioid Biomarkers as Predictors of Naltrexone Treatment Response
Mary E. McCaul, Ph.D., Johns Hopkins University

Neuroimaging of Cue-Induced Craving States
Anna Rose Childress, Ph.D., University of Pennsylvania School of Medicine

Magnetic Resonance Imaging of Cocaine-Induced Craving
Hans Breiter, M.D., Massachusetts General Hospital

Biomarkers of Addiction Revealed Through Brain Imaging: State of the Art
Edythe D. London, Ph.D.

Behavioral and Biochemical Markers

The Role of Cognitive Function Assessment in Clinical Research
Keith Wesnes, Ph.D., University of Northumbria, United Kingdom

Biomarkers of Heavy Alcohol Consumption
Raymond F. Anton, M.D., Medical University of South Carolina

Genetic Markers of Alcoholism and Alcohol Abuse
Henri Begleiter, Ph.D., State University of New York Health Science Center

Themes in the Development of Addiction-Related Biomarkers
Robert L. Stout, Ph.D., Butler Hospital

Open Discussion

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