NEUROSCIENCES III - BIOMARKERS FOR PAIN ASSESSMENT

Objectives

Modification of the function, chemistry, and structure of neurons is a major determinant of inflammatory and neuropathic pain. The challenge is to:

• Identify which signals initiate plasticity and develop markers for these
• Characterize the cellular, molecular, and physiological markers that may be involved in pain responses
• Discover the participation of novel genes in plasticity that are relevant to pain mechanisms
• Use imaging techniques to identify pain-activated areas in humans that may provide opportunities to follow effectiveness of new therapeutic approaches
• Utilize this information to improve the diagnosis and initiate novel treatment strategies for pain

Agenda

Panel I

Imaging Pain: Promise for Diagnosis
M. Catherine Bushnell, Ph.D., McGill University

Imaging Modalities and Pharmacologic Markers for Analgesia
James C. Eisenach, M.D., Wake Forest University School of Medicine

Behavioral Markers of Pain
Francis J. Keefe, Ph.D., Ohio University

Clinical Trial Design Issues for Evaluation of Pain Biomarkers
Christine Sang, M.D., M.P.H., Massachusetts General Hospital

Discussant: Mitchell Max, M.D., National Institute of Dental and Craniofacial Research

Panel II

Biomarkers for Inflammatory Pain
Jon D. Levine, M.D., Ph.D., University of California, San Francisco

Neuropathology of Pain
Robert R. Myers, Ph.D., University of California, San Diego

Quantitative Sensory Testing and Scanning Laser Doppler Fleximetry for Peripheral Nerve Injury
Gary Bennett, Ph.D., MCP Hahnemann University

Identification of Genes and Genetic Therapy for Pain
Michael Iadorola, Ph.D., National Institute of Dental and Craniofacial Research

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