CARDIOVASCULAR I - ACUTE ISCHEMIC CORONARY SYNDROMES
Background
The pathology of acute ischemia is typically related to plaque instability, thrombus
formation, and coronary flow obstruction resulting in myocardial damage. The intervention
is targeted to restore patency, whether through use of thrombolytic agents or direct
revascularization. The relevant biomarker would be related to a patency and/or perfusion
assessment. Patency can be assessed directly by angiography or indirectly by perfusion
techniques.
| Moderators: |
Victor Dzau, M.D., Brigham and Women’s Hospital
Judith Hochman, M.D., Columbia University College of Physicians and Surgeons |
Introduction
Larry Friedman, M.D., National Heart, Lung, and Blood Institute
George Sopko, M.D., M.P.H., National Heart, Lung, and Blood Institute
Targeted Topics: Acute Myocardial Infarction, Cardiogenic Shock, Unstable Angina
Angiography
David O. Williams, M.D., Brown University and Rhode Island Hospital
Jeffrey Popma, M.D., Brigham and Women's Hospital
Myocardial Imaging
Robert Bonow, M.D., Northwestern University Medical School
Franz Wackers, M.D., Yale School of Medicine
Pamela S. Douglas, M.D., Beth Israel Hospital
Myocardial Viability
Gerald M. Pohost, M.D., University of Alabama, Birmingham
Nathaniel Reichek, M.D., Medical College of Pennsylvania and MCP Hahnemann University
Plaque
Ward Casscells, M.D., University of Texas Medical School and Hermann Hospital
Zahi Fayed, Ph.D., Mount Sinai School of Medicine
Markers: ECG Serum
Bernard R. Chaitman, M.D., St. Louis University Medical Center
Allan Jaffe, M.D., State University of New York, Syracuse, Health Sciences Center
Clinical Trial Challenges
David L. DeMets, Ph.D., University of Wisconsin, Madison
| Discussant: |
Robert R. Fenichel, M.D., Ph.D., Center for Drug Evaluation
and Research, U.S. Food and Drug Administration |
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