Eighth Principal Investigators (PI) Meeting for the Innovative Molecular Analysis Technologies (IMAT) Program

July 24-25, 2007
Sofitel San Francisco Bay, Redwood City California

Agenda

Scientific Theme:

Integrating Technology Platforms:
Separation, Detection, Analysis, and Data Management

Tuesday, July 24, 2007
7:00 a.m. - 7:00 p.m.	Registration Ballroom Foyer
7:00 a.m. - 8:00 a.m.	Breakfast Ballroom Foyer
7:00 a.m. - 8:00 p.m.	Poster Setup Champagne
8:00 a.m. - 8:15 a.m.	Welcoming Remarks and Introduction of IMAT Program Bordeaux Carolyn C. Compton, M.D., Ph.D. Office of Biorepositories and Biospecimen Research National Cancer Institute, NIH J. Randy Knowlton, Ph.D. Division of Cancer Biology National Cancer Institute, NIH
8:15 a.m. - 9:00 a.m.	Keynote Speaker *Translation of Technical Development into the Clinical Laboratory* Frederic M. Waldman, M.D., Ph.D. University of California, San Francisco
9:00 a.m. - 10:20 a.m.	Scientific Session I: Gold Standards, Cool Samples, and Analysis—Part 1 Moderator: J. Randy Knowlton, Ph.D. National Cancer Institute, NIH

9:00 a.m. - 9:20 a.m.	*Evaluation of the Value of Frozen Tissue Section Used as the Gold Standard for Immunohistochemistry* Shan-Rong Shi, M.D. University of Southern California
9:20 a.m. - 9:50 a.m.	*Tissue Print Micropeels for the Molecular Profiling of Cancer* Sandra M. Gaston, Ph.D. Beth Israel Deaconess Medical Center/Harvard Medical School
9:50 a.m. - 10:20 a.m.	*Molecular Analysis of EGF Receptor (EGFR) Expression and Activation Using Nanostructured Surfaces and Liquid Crystal-Based Technologies* Paul J. Bertics, Ph.D. University of Wisconsin-Madison

10:20 a.m. - 10:40 a.m.	BREAK Ballroom Foyer
10:40 a.m. - 11:40 a.m.	Scientific Session I: Gold Standards, Cool Samples, and Analysis—Part 2 Bordeaux Moderator: J. Randy Knowlton, Ph.D. National Cancer Institute, NIH

10:40 a.m. - 11:10 a.m.	*Application of a Sensitive Double-Clad Optical Fiber for Two-Photon Fluorescence Measurement in Tissues* James R. Baker, Jr., M.D. University of Michigan
11:10 a.m. - 11:40 a.m.	*Identification of Immune-Selected Breast Cancer Antigens* Kevin Claffey, Ph.D. University of Connecticut Health Center

11:40 a.m. - 11:55 a.m.	IMAT Review Jeffrey E. DeClue, Ph.D. Division of Extramural Activities National Cancer Institute, NIH
11:55 a.m. - 12:15 p.m.	NCI/NIH Research Resources for the IMAT Investigator James W. Jacobson, Ph.D. National Cancer Institute, NIH
12:15 p.m. - 1:30 p.m.	Lunch and Posters Ballroom Foyer/Champagne
1:30 p.m. - 2:45 p.m.	The Cancer Genome Atlas (TCGA) Bordeaux Moderator: Carolyn C. Compton, M.D., Ph.D. National Cancer Institute, NIH

1:30 p.m. - 1:55 p.m.

What Is TCGA, and What Are TCGA's Technology Needs?
Daniela S. Gerhard, Ph.D.
Director, Office of Cancer Genomics
National Cancer Institute, NIH

1:55 p.m. - 2:45 p.m.

TCGA-Related Technical Developments

1:55 p.m. - 2:20 p.m.	*Exon-Specific Sequencing of Whole Genomic DNA* Darren R. Link, Ph.D. RainDance Technologies, Inc.
2:20 p.m. - 2:45 p.m.	*Mapping the Transcriptional Regulatory Networks and Epigenome of Cancer Cells: A ChIP-chip Approach* Bing Ren, Ph.D. Ludwig Institute for Cancer Research/University of California, San Diego

2:45 p.m. - 3:30 p.m.	Keynote Presentation *Pathways-Based Analysis of Cancer Progression From High-Throughput Data* Sylvia K. Plevritis, Ph.D. Stanford University
3:30 p.m. - 3:50 p.m.	BREAK Ballroom Foyer
3:50 p.m. - 5:50 p.m.	Scientific Session II: FFPE Samples: Turning Lead Into Gold Bordeaux Moderator: Lynn R. Sorbara, Ph.D. National Cancer Institute, NIH

3:50 p.m. - 4:20 p.m.	*Starting Material Degradation Test Is Tied to Success in Whole-Genome Amplification From Diverse Clinical Samples* G. Mike Makrigiorgos, Ph.D. Dana Farber Cancer Institute/Harvard Medical School
4:20 p.m. - 4:50 p.m.	*Ultrasound Tissue Fixation and Processing Achieve Superior Morphology and Macromolecule Integrity* Wei-Sing Chu, M.D. U.S. Department of Veterans Affairs
4:50 p.m. - 5:20 p.m.	*Automated, Whole-Slide-Based, Multiplexed Molecular Marker Assessment in Formalin-Fixed, Paraffin-Embedded Tissues* Richard M. Levenson, M.D. Cambridge Research & Instrumentation, Inc.
5:20 p.m. - 5:50 p.m.	*Expression Profiling in Paraffin-Embedded Tissues and Patient Cell Lines Reveals Predictive Markers in Intestinal Tumorigenesis and Colorectal Cancer Treatment* Rossanna C. Pezo, M.S. Albert Einstein College of Medicine

6:00 p.m. - 8:00 p.m.

Poster Session and Reception
Champagne

6:00 p.m. - 7:00 p.m.	*Odd poster numbers will stand by their posters for Q&A.*
7:00 p.m. - 8:00 p.m.	*Even poster numbers will stand by their posters for Q&A.*

Wednesday, July 25, 2007
7:00 a.m. - 8:00 a.m.	Breakfast and Posters Ballroom Foyer/Champagne
7:30 a.m. - 3:30 p.m.	Registration Ballroom Foyer
8:00 a.m. - 10:20 a.m.	$$$Future Potential$$$ Bordeaux Moderator: Jennifer Couch, Ph.D. Division of Cancer Biology National Cancer Institute, NIH

8:00 a.m. - 8:40 a.m.

Topic 1: Downstream Funding Opportunities

8:00 a.m. - 8:15 a.m.	Jennifer Couch, Ph.D. Division of Cancer Biology National Cancer Institute, NIH
8:15 a.m. - 8:40 a.m.	Rohit K. Shukla, M.A. Commercialization Assistance Program Representative Larta Institute

8:40 a.m. - 10:20 a.m.

Topic 2: Technology Transfer

8:40 a.m. - 8:55 a.m.	Kevin Brand, J.D. Technology Transfer Center National Cancer Institute, NIH
8:55 a.m. - 9:10 a.m.	J.P. Kim, J.D., M.B.A., M.S. Division of Extramural Inventions and Technology National Cancer Institute, NIH
9:10 a.m. - 9:25 a.m.	Wendy D. Streitz, M.S.E.E. Policy, Analysis, and Campus Services University of California System
9:25 a.m. - 9:40 a.m.	Novel 3-D Tissue Imaging: A Multi-Dimensional Story of Technology Development Bevin P. Engelward, Sc.D. Massachusetts Institute of Technology
9:40 a.m. - 10:20 a.m.	Panel Discussion for Technology Transfer Extramural Community (Licensing Technologies, Intellectual Properties, and Patent MTAs and CDAs)

10:20 a.m. - 10:40 a.m.	BREAK Ballroom Foyer
10:40 a.m. - 11:25 a.m.	Keynote Presentation Bordeaux *Genomic Data Management and Analysis: Good, Bad, and Ugly* Timothy J. Triche, M.D., Ph.D. Children's Hospital Los Angeles
11:25 a.m. - 12:30 p.m.	Lunch and Posters Ballroom Foyer/Champagne
12:30 p.m. - 3:30 p.m.	Scientific Session III: Circulating Cells: Catch Me If You Can Moderator: James W. Jacobson, Ph.D. National Cancer Institute, NIH

12:30 p.m. - 1:00 p.m.	*Integrated Polymer-Based Microfluidic Systems for the Efficient Capture and Enumeration of Circulating Tumor Cells (CTCs) From Peripheral Blood* Steven A. Soper, Ph.D. Louisiana State University
1:00 p.m. - 1:30 p.m.	*Chip-Based RNA Sensor Platform for the Detection of Circulating Tumor Cells* Gary A. Clawson, M.D., Ph.D. The Pennsylvania State University
1:30 p.m. - 2:00 p.m.	*Activity-Based Probes for Profiling Histone Deacetylase Complexes in Proteomes* Cleo M. Salisbury, Ph.D. The Scripps Research Institute
2:00 p.m. - 2:30 p.m.	*Developing Proteomic Technologies for Rapid, Real-Time, Label-Free Detection of Protein Interactions* Niroshan Ramachandran, Ph.D. Harvard Medical School/Dana-Farber Cancer Institute
2:30 p.m. - 3:00 p.m.	*Clinical Application of Multispectral Imaging Flow Cytometry* Hans Minderman, Ph.D. Roswell Park Cancer Institute
3:00 p.m. - 3:30 p.m.	*Phosphoprotein Profiling for Quantitative Analysis of Protein Phosphorylation Patterns* Stephen Kron, M.D., Ph.D. The University of Chicago

3:30 p.m.

Adjournment and Poster Removal