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National Cancer Institute
Physical Sciences in Oncology Network Investigators Meeting


Agenda

A summary of the tutorials on Sunday morning (April 10th) can be found in the tutorial section.

Sunday, April 10

7:00 a.m. - 5:30 p.m.

Registration - Room X Lobby

7:00 a.m.  - 5:30 p.m.

Poster Setup - Room X Lobby

7:00 a.m. - 8:00 a.m.

Continental Breakfast

8:00 a.m. -10:15 a.m.

Pathology Boot Camp (three 45 min sessions) - Scripps Clinic

8:00 a.m. - 11:30 a.m.

Tutorial Sessions - Room X
Moderator: Denis Wirtz
Johns Hopkins University
Johns Hopkins University PS-OC

8:00 a.m. - 8:30 a.m.

An Overview of the PS-OC Bioresource Core Facility (PBCF)
Yvonne A. Reid, PhD
ATCC
PS-OC Bioresource Core Facility

8:30 a.m. - 9:15 a.m.

Applications of Nanobiotechnology
Michael L. Shuler, PhD
Cornell University
Cornell University PS-OC

9:15 a.m. – 10:00 a.m.

An overview of blood coagulation and cancer metastasis
Owen McCarty, PhD
Oregon Health Science University
The Scripps Research Institute PS-OC

10:00 a.m. - 10:30 a.m.

Break

10:30 a.m. – 11:30 a.m.

Show Case Tumor Board
Jorge Nieva, MD
Medical Oncology, Billings Clinic
The Scripps Research Institute PS-OC

Ludmila Bazhenova, MD
Thoracic Medical Oncology, University of California, San Diego
The Scripps Research Institute PS-OC

Kelly Bethel, MD
Anatomical Pathology, Scripps Clinic
The Scripps Research Institute PS-OC

Arno Mundt, MD
Radiation Oncology, University of California, San Diego
The Scripps Research Institute PS-OC

Randy Schaffer, MD
Surgery, Scripps Clinic
The Scripps Research Institute PS-OC

Robert A. Gatenby, MD
Clinical Imaging, H. Lee Moffitt Cancer Center & Research Institute
H. Lee Moffitt Cancer Center & Research Institute PS-OC

11:30 a.m. - 1:00 p.m.

Lunch - Room TBD

11:30 a.m. - 1:00 p.m.

Working Lunch Sessions

PS-OC Young Investigators Trans-Network - Room X
Projects Information Session

PS-OC Evolution of Drug Resistance Working - Room TBD
Group Presentation

PS-OC Outreach and Dissemination Working - Room TBD
Group Meeting

12 noon - 1:00 p.m.

PS-OC Trans-Network Introduction (Panelist Only) - Room TBD

1:00 p.m. - 5:15 p.m.

PS-OC Trans-Network Project - Room X

5:30 p.m. – 6:00 p.m.

PS-OC Trans-Network Proposal Debrief (Panelists Only) - Room TBD

5:30 p.m. - 7:30 p.m.

Poster Session and Reception - Room TBD
ODD number posters present at this time.

Monday, April 11

7:00 a.m. - 5:00 p.m.

Registration - Room X Lobby

7:00 a.m. - 8:00 a.m.

Continental Breakfast - Room X Lobby

8:00 a.m. - 8:10 a.m.

NCI Welcome and Opening Remarks - Room X

8:10 a.m. - 8:15 a.m.

Patient Advocate Perspective
Carole Bass

8:15 a.m. - 8:20 a.m.

Introductions - Meeting Objective
Larry A. Nagahara, PhD
National Cancer Institute, NIH

8:20 a.m. - 10:05 a.m.

Plenary Talks (30 min talk/5 min discussion)

10:05 a.m. - 10:30 a.m.

Break

10:30 a.m. - 12:10 p.m.

Session 1: Determining if there is and/or defining a fundamental equation of cancer?
Moderator: W. Daniel Hillis, PhD
Applied Minds
University of Southern California PS-OC

10:30 a.m. - 10:50 a.m.

Why Cancer is so Smart: the Atavism Explanation
Paul Davies, PhD
Arizona State University
Arizona State University PS-OC

10:50 a.m. - 11:10 a.m.

Thermodynamics of living systems: prokaryotes, eukaryotes, and cancer
Robert A. Gatenby, MD
H. Lee Moffitt Cancer Center & Research Institute
H. Lee Moffitt Cancer Center & Research Institute PS-OC

11:10 a.m. - 11:30 a.m.

Patient -calibrated modeling of ductal carcinoma in situ (DCIS): From microscopic measurements to macroscopic predictions of clinical progression
Paul Macklin, PhD
University of Dundee
University of Southern California PS-OC

11:30 a.m. - 11:50 a.m.

Experimental Tests of the Fundamental Equation of Cancer
Robert Austin, PhD
Princeton University
Princeton University PS-OC

11:50 a.m. - 12:20 p.m.

Discussion

12:20 p.m. - 1:50 p.m.

Lunch - Room TBD

12:20 p.m. - 1:50 p.m.

Working Lunch Sessions

PS-OC Physics Working Group Meeting - Room TBD

PS-OC Education and Training Working - Room TBD
Group Meeting

12:30 p.m. – 3:30 p.m.

PS-OC Trans-Network Proposal Review (Panelist Only) - Room X

1:50 p.m. - 3:10 p.m.

Session 2: Understanding the implications of tumor heterogeneity
Moderator: Thea Tlsty, PhD
University of California, San Francisco
Princeton University PS-OC

1:50 p.m. - 2:10 p.m.

Single molecule transcript counting of stem cell markers in the mouse intestine
Alexander van Oudenaarden, PhD
Massachusetts Institute of Technology
Massachusetts Institute of Technology PS-OC

2:10 p.m. - 2:30 p.m.

Varying microenvironmental oxygen tension as a critical regulator of tumor heterogeneity
Claudia Fischbach, PhD
Cornell University
Cornell University PS-OC

2:30 p.m. - 2:50 p.m.

Title TBD
TBD (Kuhn or Newton)
The Scripps Research Institute
The Scripps Research Institute PS-OC

2:50 p.m. - 3:10 p.m.

Discussion

3:10 p.m. - 3:40 p.m.

Break

3:40 p.m. - 5:00 p.m.

Session 3: Performing Physical Science Measurements
Moderator: Kelly Bethel, MD
Scripps Clinic
The Scripps Research Institute PS-OC

3:40 p.m. - 4:00 p.m.

Alterations in nuclear nanoscale architecture: optical imaging and the role in early carcinogenesis
Vadim Backman, PhD
Northwestern University
Northwestern University PS-OC

4:00 p.m. - 4:20 p.m.

Size, growth rate and stiffness regulation in normal and cancer cells
Scott Manalis, PhD
Massachusetts Institute of Technology
Massachusetts Institute of Technology PS-OC

4:20 p.m. - 4:40 p.m.

A novel light microscope capable of visualizing tumor mechanics in living tissues
Jan Liphardt, PhD
University of California, Berkeley
University of California, Berkeley PS-OC

4:40 p.m. - 5:00 p.m.

Discussion

5:00 p.m. - 7:00 p.m.

Poster Session and Reception - Room TBD
EVEN number posters present at this time.

7:00 p.m. - 9:30 p.m.

PS-OC Steering Committee Working Dinner (by invitation) - Room TBD

Tuesday, April 12

7:00 a.m. - 2:30 p.m.

Registration - Room X Lobby

7:00 a.m. - 8:00 a.m.

Continental Breakfast - Room X Lobby

8:00 a.m. - 8:15 a.m.

PS-OC Network Update - Room X
Larry A. Nagahara, PhD
National Cancer Institute, NIH

8:15 a.m. - 8:25 a.m.

PS-OC Poster, Young Investigators - Room X
Trans-Network Project Awards

8:25 a.m. – 10:00 a.m.

Plenary Talks (30 min talk/5 min discussion) - Room X

10:00 a.m. - 10:30 a.m.

Break

10:30 a.m. - 11:50 a.m.

Session 4: Understanding the Role of “Seed” and “Soil” in Metastasis
Moderator: Valerie Weaver, PhD
University of California, San Francisco
University of California, Berkeley PS-OC

10:30 a.m. – 10:50 a.m.

When seeds stick: selectin-mediated adhesion of circulating tumor cells to vascular endothelium
Michael King, PhD
Cornell University
Cornell University PS-OC

10:50 a.m. – 11:10 a.m.

Metastasis of low-fitness cells: rare, explosive, and deterministic
Timothy Newman, PhD
Arizona State University
Arizona State University PS-OC

11:10 a.m. – 11:30 a.m.

Thinking locally: The importance of physical microenvironmental heterogeneity in governing tumor cell motility
Sanjay Kumar, PhD
University of California, Berkeley
University of California, Berkeley PS-OC

11:30 a.m. – 11:50 a.m.

Discussion

11:50 am - 1:00 p.m.

Lunch - Room TBD

12 noon - 1:00 p.m.

Working Lunch Sessions
Program/Activities within NCI - Room X
X
Y
Z

1:00 p.m. - 2:40 p.m.

Session 5: Understanding if cancer should be treated as a curable or manageable disease
Moderator: Steven A. Curley, MD
University of Texas, MD Anderson Cancer Center
The Methodist Hospital Research Institute PS-OC

1:00 p.m. – 1:20 p.m.

Targeting the Hallmarks of Cancer
Robert J. Gillies, PhD
H. Lee Moffitt Cancer Center & Research Institute
H. Lee Moffitt Cancer Center & Research Institute PS-OC

1:20 p.m. – 1:40 p.m.

Resistance to the chemotherapy, paclitaxel, increases the sensitivity to other microenvironmental stresses in prostate cancer cells
Robert H. Getzenberg, PhD
Johns Hopkins University
Princeton University PS-OC

1:40 p.m. – 2:00 p.m.

A mathematical framework based on pancreatic cancer autopsy data reveals dynamics of metastatic dissemination and suggests optimum treatment strategies
Franziska Michor, PhD
Dana-Farber Cancer Institute
Dana-Farber Cancer Institute PS-OC

2:00 p.m. – 2:20 p.m.

Title TBD (Clinical Perspective)
David Agus, MD
University of Southern California
University of Southern California PS-OC

2:20 p.m. – 2:50 p.m.

Discussion

2:50 p.m. – 3:00 p.m.

Wrap-up and Adjournment
Larry A. Nagahara, PhD
National Cancer Institute, NIH


Second Annual Physical Sciences in Oncology Meeting
April 10 - 12, 2011
Hyatt Regency La Jolla at Aventine