Monday, March 28 |
NDC Translational Path |
7:45 a.m. - 9:00 a.m. |
Registration and Light Refreshments |
8:15 |
NIH Nanomedicine Initiative Project Team Meets With Clinical Consulting Boards
(Cartier/Tiffany Rooms) |
8:45 |
Welcome and Introductions
Richard Fisher, Ph.D.
Jeffery Schloss, Ph.D.
Paul Sieving, M.D., Ph.D.
NIH Nanomedicine Initiative Project Team |
8:55 |
NIH Common Fund
James Anderson, M.D., Ph.D.
Director
NIH Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, NIH |
9:10 |
Translational Research at the NIH
Rajesh Ranganathan, Ph.D.
Office of the Director, NIH |
9:30 |
Nanomedicine Center for Mechanobiology Directing the Immune Response
T-Cell Adoptive Therapy in the Clinic: The Importance of Cell Culture Technology
Carl June, M.D.
University of Pennsylvania
Regulation of T-Cell Activation and Expansion by Control of the Stimulatory Substrate Elasticity
Michael Milone, M.D., Ph.D.
University of Pennsylvania
Nanoscale Materials for Improved Activation and Expansion of T Cells
Lance Kam, Ph.D., M.S.
Columbia University
|
10:20 |
Center for Protein Folding Machinery
Chaperonin-Based Therapies for Huntingon’s Disease and Von Hippel-Lindau Disease
Eric Jonasch, M.D.
The University of Texas MD Anderson Cancer Center
|
11:10 |
Break |
11:25 |
Center for Cell Control
CCC’s Translation Pathway-Manipulating Key Protein Complexes by Combinatorial Medicine
Chih-Ming Ho, Ph.D.
University of California, Los Angeles
|
11:45 |
NDC for the Optical Control of Biological Function
Restoration of Vision-I: One-Component Photoswitch Systems
Russell Van Gelder, M.D., Ph.D.
University of Washington
Restoration of Vision-II: Two-Component Photoswitch Systems
John Flannery, Ph.D.
University of California, Berkeley
Restoration of Vision-III: Primate Model
William Merigan, Ph.D.
University of Rochester
Restoration of Vision-IV: Canine Models of Inherited Retinal Degeneration
William Beltran, D.V.M., Ph.D.
University of Pennsylvania
|
12:35 p.m. |
Lunch and Posters
(Waterford/Lalique Rooms)
(Even-numbered posters will be presented during this time.) |
2:00 |
Engineering Cellular Control: Synthetic Signaling and Motility Systems
Engineering Cellular Control: Synthetic Signaling and Motility Systems
Wendell Lim, Ph.D.
University of California, San Francisco
|
2:20 |
Nanomedicine Center for Nucleoprotein Machines
Development of a Nanomedicine Platform Technology To Cure Sickle Cell Disease
Steffen Meiler, M.D.
Georgia Health Sciences University
Using the Concepts of Nanomedicine To Cure Sickle Cell Disease: Challenges and the Path Forward
Matthew Porteus, M.D., Ph.D.
Stanford University
ZFN Delivery: Transformative Approaches for the Translational Path
William Dynan, Ph.D.
Georgia Health Sciences University
Hematopoietic Stem-Cell Transplantation Using Genetically Corrected Stem Cells for the Treatment of Sickle Cell Disease
Adam Hartigan, Ph.D.
Joslin Diabetes Center and Harvard Medical School
|
3:10 |
Break |
3:30 |
Translational Considerations and Discussion
Engineering T Cells for HIV Resistance: Bench-to-Bedside Lessons
Carl June, M.D.
University of Pennsylvania
Lessons Learned From the NCI’S Nanotechnology Characterization Laboratory
Scott McNeil, Ph.D.
Nanotechnology Characterization Laboratory, NCI, NIH
The FDA Review Process for Clinical Trials
Andrew Byrnes, Ph.D.
U.S. Food and Drug Administration
Steven Fleischer, D.V.M.
U.S. Food and Drug Administration
Toxicity Considerations
Martin Philbert, Ph.D.
University of Michigan
Panel Discussion |
~5:30 |
Evening Poster and Networking Session |
Tuesday, March 29th |
NDC Progress |
8:00 a.m. |
Registration and Light Refreshments |
8:30 |
Nanomedicine Center for Nucleoprotein Machines
Nanomedicine Center for Nucleoprotein Machines: A Progress Overview
Gang Bao, Ph.D.
Georgia Institute of Technology and Emory University
Transferrin-Conjugated Zinc Finger Nucleases for Gene Correction: Production, Delivery, and Characterization
Janmejay Pandey, Ph.D.
Georgia Health Sciences University
Genetic Engineering of Mutant ZFNs for the Development of Photoswitchable ZFNs
Yiyi Zhang, Ph.D.
Georgia Institute of Technology
Examination of Repair Pathway Choice Between the NHEJ and HR Nanomachineries Upon Zinc Finger Nuclease-Induced Double-Strand Breaks
R. Ileng Kumaran, Ph.D.
Cold Spring Harbor Laboratory
Detecting Off-Target ZFN-Induced Rearrangements Genome-Wide
Martina Mijuskovic, Ph.D.
New York University
|
9:30 |
NDC for the Optical Control of Biological Function
Light-Gated Receptors: From Cells to Intact Circuits
Ehud Isacoff, Ph.D.
University of California, Berkeley, and Lawrence Berkeley National Laboratory
Optochemical Genetics
Martin Sumser, Ph.D.
Ludwig-Maximilians University
Optical Manipulation of Pain Circuits
Richard Kramer, Ph.D.
University of California, Berkeley
|
10:30 |
Break |
11:00 |
Center for Cell Control
Attacking Signaling Complexes To Battle Leukemia
Michael Teitell, M.D., Ph.D.
University of California, Los Angeles
Application of PhosphoFlow and CyTOF Technologies To Dissect Roles of Protein Complexes in Disease Treatment
Garry Nolan, Ph.D.
Stanford University
Tunable Nanoplasmonic Resonators and Optoelectronic Tweezers
Ming Wu, Ph.D.
University of California, Berkeley
Developing Clinically Enabling Human Embryonic Stem-Cell Culture Through Feedback System Control
Hideaki Tsutsui, Ph.D.
University of California, Los Angeles
|
12:00 p.m. |
Lunch and Posters
(Waterford/Lalique Rooms)
(Odd-numbered posters will be presented during this time.) |
1:30 |
Center for Protein Folding Machinery
Neuroprotective Role(s) of TRiC Subunits Against Axonal Dysfunction Caused by Mutant Huntingtin: A Live Imaging Study of Axonal Transport of Neurotrophic Signals
Willam Mobley, M.D., Ph.D.
University of California, San Diego
ApiCCT1 Modulates Mutant Htt Phenotypes
Emily Mitchell
University of California, Irvine
A Direct In Vivo Assay in Mouse Stratum for the Modulation of Huntington’s Disease Pathology by the Eukaryotic Chaperonin Tric
David Housman, Ph.D.
Massachusetts Institute of Technology
|
2:30 |
Engineering Cellular Control: Synthetic Signaling and Motility Systems
Synthetic Biology in Translational Medicine: Engineering T-Cell Responses for Cancer Therapy
Wilson Wong, Ph.D.
University of California San Francisco
Engineering Cellular Homing Systems and Cargo-Carrying Capabilities To Enhance Cell-Based Cancer Therapy
Jason Park, M.Eng.
University of California San Francisco
Engineering Complex Therapeutic Vesicles
Ross Rounsevell, Ph.D., M.S.
University of California, Berkeley
|
3:30 |
Break |
3:45 |
Nanomedicine Center for Mechanobiology Directing the Immune Response
T-Cell Mechanotransduction Studies Based on CasL, Myosin II, Talin, and Fibronectin Fibrils
Michael Dustin, Ph.D.
New York University
Search for Regulators and Modulators of Rigidity Sensing
Benny Geiger, Ph.D.
Weizmann Institute
Large-Scale Learning of Immune System Regulatory Modules and Networks: Application to T-Cell Differentiation and Function
Richard Bonneau, Ph.D.
New York University
Screening of T-Cell Activation With Nanostructured Substrates
Alexander Gondarenko, Ph.D.
Columbia University
|
4:45 |
CLOSING REMARKS |
