NCI Nanotechnology Alliance Investigators Meeting


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NCI Nanotechnology Alliance Investigators Meeting, October 25-26, 2006, San Diego, California

Agenda
Tuesday, October 24, 2006
5:00 p.m. - 8:00 p.m. Registration - Salons E-H, La Jolla Ballroom Foyer
6:00 p.m. - 8:00 p.m. Commercialization Forum - Salons F-H, La Jolla Ballroom

Session Chair:
Sadik C. Esener, Ph.D.
University of California, San Diego

Invited Speakers:
Patrick Soon-Shiong, M.D.
Chairman of the Board and Chief Executive Officer
Abraxis BioScience, Inc.

Andrew "Drew" E. Senyei, M.D.
General Partner and Managing Director
Enterprise Partners Venture Capital

Claude D. Benchimol, Ph.D.
Senior Vice President of Research and Development
Invitrogen Corporation

David R. Parkinson, M.D.
Senior Vice President, Oncology Research and Development
Biogen Idec
Wednesday, October 25, 2006
7:00 a.m. - 6:30 p.m. Registration - Salons E-H, La Jolla Ballroom Foyer
7:00 a.m. - 8:00 a.m. Breakfast - Salons E-H, La Jolla Ballroom Foyer
8:00 a.m. - 8:30 a.m. Opening Remarks - Salons E-H, La Jolla Ballroom

Anna D. Barker, Ph.D.
Deputy Director, Advanced Technologies and Strategic Partnerships
National Cancer Institute, NIH

Sadik C. Esener, Ph.D.
University of California, San Diego
8:30 a.m. - 9:00 a.m. Plenary Presentation - Salons E-H, La Jolla Ballroom

Clinical Promise of Nanomedicine: Delivery and Penetration of Pathways Into Solid Tumors
Jan E. Schnitzer, M.D.
Scientific Director
Sidney Kimmel Cancer Center
9:00 a.m. - 10:00 a.m. Session I: In Vivo Diagnostics and Imaging - Salons E-H, La Jolla Ballroom

Session Chair:
Sanjiv Sam Gambhir, M.D., Ph.D.
Stanford University

NCI Moderator:
Jerry S.H. Lee, Ph.D.
National Cancer Institute, NIH

Speakers:
Improved Magnetofluorescent Nanoparticles for Cancer Detection
Lee Josephson, Ph.D.
Harvard Medical School and
Massachusetts General Hospital

In Vivo Imaging With Quantum Dots
Jianghong Rao, Ph.D.
Stanford University

PET Imaging and Use of Microfluidics for Rapid Synthesis of Radiolabeled Molecular Imaging Probes
Michael E. Phelps, Ph.D.
University of California, Los Angeles

Bioactivated Nanoprobes for Molecular Imaging of Cancer
Thomas J. Meade, Ph.D.
Northwestern University
10:00 a.m. - 10:30 a.m. Discussion - Salons E-H, La Jolla Ballroom
10:30 a.m. - 10:45 a.m. Break
10:45 a.m. - 11:15 a.m. Session I: In Vivo Diagnostics and Imaging (continued):
Research Enablers (Animal Model/Toxicology)
- Salons E-H, La Jolla Ballroom

Speakers:
Intraperitoneally Administered Nanoporous Silicon Particles for the Treatment of Ovarian Cancer
Stephen B. Howell, M.D.
University of California, San Diego

Molecularly Tailored Mouse Models of Cancer for In Vivo Applications of Nanomedical Sciences
Alan Charest, Ph.D.
Massachusetts Institute of Technology
11:15 a.m. - 11:45 a.m. Discussion - Salons E-H, La Jolla Ballroom
11:45 a.m. - 2:00 p.m. Lunch - First Floor, Fountain Court
(Lunch will stop being served at 1:30 p.m.)

Poster Session I - First Floor, Newport and Irvine and Salons E-H Foyer
12 noon - 1:00 p.m. Bioinformatics in Nanotechnology Working Group Luncheon - Third Floor, Santa Barbara Room
2:00 p.m. - 2:30 p.m. Keynote Presentating - Salons E-H, La Jolla Ballroom
Thomas Kalil
Special Assistant to the Chancellor for Science and Technology
University of California, Berkeley
2:30 p.m. - 3:45 p.m. Session II: Nanotherapeutics - Salons E-H, La Jolla Ballroom

Session Chair:
Gregory M. Lanza, M.D., Ph.D.
Washington University in Saint Louis

NCI Moderator:
Linda K. Molnar, Ph.D.
National Cancer Institute, NIH

Speakers:
Targeting Nanoparticles to the Tumor Endothelium
David A. Cheresh, Ph.D.
University of California, San Diego

Nanotechnology in Drug Delivery
James R. Baker, Jr., M.D.
University of Michigan

Photodestruction of Ovarian Cancer: ErbB3 Targeted Aptamer-Nanoparticle Conjugate
Tayyaba Hasan, Ph.D.
Harvard Medical School and
Massachusetts General Hospital

Nanoparticle Therapeutics: Examples and Outlook
Samuel A. Wickline, M.D.
Washington University in Saint Louis

How Can the NCI Nanotechnology Alliance Access the Drug Development Capabilities of the NCI?
Joseph Tomaszewski, Ph.D.
Deputy Director, Division of Cancer Treatment and Diagnosis
National Cancer Institute, NIH
3:45 p.m. - 4:15 p.m. Discussion - Salons E-H, La Jolla Ballroom
4:15 p.m. - 4:30 p.m. Break
4:30 p.m. - 5:15 p.m. Session II: Nanotherapeutics (continued):
Research Enablers (Targeting Strategies)
- Salons E-H, La Jolla Ballroom

Speakers:
Targeting Strategies: Engineered Antibodies and Proteins
Anna M. Wu, Ph.D.
University of California, Los Angeles

Ligand-Directed Perfluorocarbon Nanoparticles: The Issue of Targeting
Gregory M. Lanza, M.D., Ph.D.
Washington University in Saint Louis

Aptamers and Cancer Nanotechnology
Omid Farokhzad, M.D.
Brigham and Women's Hospital and Harvard Medical School
5:15 p.m. - 5:45 p.m. Discussion - Salons E-H, La Jolla Ballroom
6:30 p.m. - 10:00 p.m. Evening Event: Birch Aquarium at Scripps
2300 Expedition Way, La Jolla, California
    6:30 p.m.     Buses depart for the Birch Aquarium at Scripps.
    Hotel Lobby Buses run consistently from 6:30 p.m. - 10:00 p.m.
    6:30 p.m. - 7:15 p.m.     Reception
    7:15 p.m. - 8:00 p.m.     Dinner
    8:00 p.m. - 8:30 p.m.     Keynote Presentation:
    Evolution of Cancer Therapeutics

    David R. Parkinson, M.D.
    Senior Vice President, Oncology Research and Development
    Biogen Idec
    10:00 p.m.     Last bus leaves the Birch Aquarium at Scripps for the hotel.
Thursday, October 26, 2006
7:30 a.m. - 5:00 p.m. Registration - Salons E-H, La Jolla Ballroom Foyer
7:30 a.m. - 8:25 a.m. Breakfast - Salons E-H, La Jolla Ballroom Foyer
8:25 a.m. - 8:30 a.m. Morning Remarks - Salons E-H, La Jolla Ballroom
Piotr Grodzinski, Ph.D.
National Cancer Institute, NIH
8:30 a.m. - 9:45 a.m. Session III: Nanomaterials in Biological Matrices - Salons E-H, La Jolla Ballroom

Session Chair:
Mauro Ferrari, Ph.D.
University of Texas Health Science Center, Houston

NCI Moderator:
Travis M. Earles
National Cancer Institute, NIH

Speakers:
"Mother Ships" for Nanodiagnostics and Nanotherapeutics
Michael J. Sailor, Ph.D.
University of California, San Diego

Bridging the Imaging Gap in Nanobiology With Three-Dimensional Electron Microscopy
Sriram Subramaniam, Ph.D.
National Cancer Institute, NIH

Multifunctional Nanoparticle Probes for In Vivo Cancer Imaging
Shuming Nie, Ph.D.
Georgia Institute of Technology and Emory University

Anti-Biobarrier Nanotechnologies
Mauro Ferrari, Ph.D.
University of Texas Health Science Center, Houston

Organic Delivery Vehicles for Probing and Treating Biological Systems: Adapting Fabrication Processes From the Electronics Industry for Use in Nanomedicine
Joseph M. DeSimone, Ph.D.
The University of North Carolina at Chapel Hill
9:45 a.m. - 10:15 a.m. Discussion - Salons E-H, La Jolla Ballroom
10:15 a.m. - 10:30 a.m. Break
10:30 a.m. - 11:10 a.m. Panel: Clinical Pathways for Nanotechnology - Salons E-H, La Jolla Ballroom

Speakers:
Characterization of Nanomaterials Intended for Medical Applications
Scott E. McNeil, Ph.D.
Director, Nanotechnology Characterization Laboratory
SAIC-Frederick, Inc.
National Cancer Institute, NIH

Nanotechnology: Stimulating Innovation Through Collaboration With the U.S. Food and Drug Administration
Wendy R. Sanhai, Ph.D.
Senior Scientific Advisor, Office of the Commissioner
U.S. Food and Drug Administration

Medical Nanodevices - Regulatory Perspectives
Subhas G. Malghan, Ph.D.
Deputy Director
Center for Devices and Radiological Health
U.S. Food and Drug Administration
11:10 a.m. - 11:30 a.m. Question and Answer Session - Salons E-H, La Jolla Ballroom
11:30 a.m. - 12 noon Multidisciplinary Research Training and Team Development - Salons E-H, La Jolla Ballroom

NCI Moderator:
Travis M. Earles
National Cancer Institute, NIH

Speakers:
Sri Sridhar, Ph.D.
Northeastern University

Carolyn J. Anderson, Ph.D.
Washington University in Saint Louis

Joanne Mortimer, M.D.
University of California, San Diego
11:30 a.m. - 1:45 p.m. Poster Session II - First Floor, Newport and Irvine and Salons E-H Foyer
12 noon - 1:45 p.m. Lunch - First Floor, Fountain Court
(Lunch will stop being served at 1:30 p.m.)
12:15 p.m. - 1:45 p.m. Coordinating and Governance Committee (CGC) Luncheon Meeting - Third Floor, San Francisco
(invitation only)
1:45 p.m. - 2:45 p.m. Session IV: In Vitro Diagnostics - Salons E-H, La Jolla Ballroom

Session Chair:
James R. Heath, Ph.D.
California Institute of Technology

NCI Moderator:
Piotr Grodzinski, Ph.D.
National Cancer Institute, NIH

Speakers:
Integrated System for Cancer Biomarker Detection
Scott Manalis, Ph.D.
Massachusetts Institute of Technology

Simultaneous and Quantitative Detection of Multiple Biomarkers in Human Breast Cancers Using Semiconductor Multicolor Quantum Dots
Ruth M. O'Regan, M.D.
Emory University

Carbon Nanomaterials for Biological Applications
Hongjie Dai, Ph.D.
Stanford University

Deconstructing Directional Cell Motility in Cancer Metastasis Through Nanopatterning
Bartosz A. Grzybowski, Ph.D.
Northwestern University
2:45 p.m. - 3:15 p.m. Discussion - Salons E-H, La Jolla Ballroom
3:15 p.m. - 3:30 p.m. Break
3:30 p.m. - 4:15 p.m. Session IV: In Vitro Diagnostics (continued):
Research Enablers (Capture Agents/Technology Scale-Up)
- Salons E-H, La Jolla Ballroom

Speakers:
Molecular Profiling of Murine Models and Human Prostate Cancer for Pathway-Specific Biomarker Discovery
Thomas Graeber, Ph.D.
University of California, Los Angeles

Science and Regulatory Perspectives of Medical Devices Using Nanotechnology
Subhas G. Malghan, Ph.D.
Deputy Director
Center for Devices and Radiological Health
U.S. Food and Drug Administration

Commercialization of Life Sciences Technologies: An Experience
J. Michael Ramsey, Ph.D.
The University of North Carolina at Chapel Hill
4:15 p.m. - 4:45 p.m. Discussion - Salons E-H, La Jolla Ballroom
4:45 p.m. - 5:00 p.m. Closing Remarks - Salons E-H, La Jolla Ballroom
5:00 p.m. Adjournment