NCI Nanotechnology Alliance Investigators Meeting


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Registration 		NCI Nanotechnology Alliance Investigators Meeting, October 16-18, 2007, Chapel Hill, NC

Agenda
Tuesday, October 16, 2007
8:00 a.m. - 7:00 p.m. Registration (Atrium)
9:00 a.m. - 10:00 a.m. Tutorial Session 1: Cells, Tissues, and Organs: Basic Principles of Functional Histology and Pathology (Grumman Auditorium)

This tutorial will provide a basic understanding of histology and pathology of the human body and address the importance of the procurement and handling of research specimens in the understanding, diagnosis, and treatment of cancer.

Speaker: Carolyn C. Compton, M.D., Ph.D.
Office of Biorepositories and Biospecimen Research
National Cancer Institute, NIH
10:00 a.m. - 11:00 a.m. Tutorial Session 2: Basic Cancer Biology (Grumman Auditorium)

This tutorial will deal with oncogenes, tumor suppressor genes, and signaling pathways involved in tumor initiation and progression.

Speaker: Channing Der, Ph.D.
Department of Pharmacology
University of North Carolina at Chapel Hill
11:00 a.m. - 12 noon Tutorial Session 3: Animal Models (Grumman Auditorium)

This tutorial will deal with the role of animal models in cancer research, with an emphasis on genetically engineered mouse models.

Speaker: Terry A. Van Dyke, Ph.D.
Lineberger Comprehensive Cancer Center
University of North Carolina at Chapel Hill
12 noon - 1:00 p.m. Lunch (Trillium Room)
1:00 p.m. - 2:00 p.m. Tutorial Session 4: Biodistribution of Nanoparticles (Grumman Auditorium)

This tutorial will deal with the physical and physiological parameters that control the pharmacokinetics and biodistribution of nanoparticles in vivo.

Speaker: Leaf Huang, Ph.D.
School of Pharmacy
University of North Carolina at Chapel Hill/
North Carolina State University
2:00 p.m. - 3:00 p.m. Tutorial Session 5: Materials Science/Nanotechnology (Grumman Auditorium)

This tutorial will be an introduction to the basic concepts in materials science and nanotechnology for biomedical scientists.

Speaker: Joseph M. DeSimone, Ph.D.
Departments of Chemistry and Chemical Engineering
University of North Carolina at Chapel Hill/
North Carolina State University
3:00 p.m. - 3:30 p.m. Break
3:30 p.m. - 5:00 p.m. Working Group Breakout Sessions

Nanotheranostics Working Group (Dogwood A)

Diagnostics, Imaging, and Sensing Working Group (DISWG) (Dogwood B)

Communications and Integration Working Group (CIWG) (Redbud B)
5:00 p.m. - 6:00 p.m. Reception (Atrium)
6:00 p.m. - 7:35 p.m. Clinical Pathway (Grumman Auditorium)
Moderator: Piotr Grodzinski, Ph.D.
National Cancer Institute, NIH

Steps to Take Prior to IND Submission
Roy Wu, Ph.D.
Clinical Grants and Contracts Branch
National Cancer Institute, NIH

Creating a Critical Path to Nanotechnology Product Development
Wendy R. Sanhai, Ph.D.
Office of the Commissioner
U.S. Food and Drug Administration

Overview of the Nanotechnology Characterization Laboratory
Scott E. McNeil, Ph.D.
Nanotechnology Characterization Laboratory
SAIC-Frederick, Inc.
National Cancer Institute, NIH

caBIG: Advancing Molecular Medicine
Anand Basu, M.B.A.
Center for Biomedical Informatics and Information Technology
National Cancer Institute, NIH
Wednesday, October 17, 2007
7:00 a.m. - 6:00 p.m. Registration (Atrium)
7:00 a.m. - 8:00 a.m. Continental Breakfast (Grumman Auditorium)
7:00 a.m. Poster Setup Begins (Atrium, Belflower)
(All posters setup by 9:45 a.m.) (Windflower, Willow)
8:00 a.m. - 8:30 a.m. Opening Remarks (Grumman Auditorium)

Rudy Juliano, Ph.D.
University of North Carolina at Chapel Hill

H. Shelton Earp, M.D.
University of North Carolina at Chapel Hill

Anna D. Barker, Ph.D.
National Cancer Institute, NIH
8:30 a.m. - 9:45 a.m. Plenary Session (Grumman Auditorium)
Chair: Piotr Grodzinski, Ph.D.
National Cancer Institute, NIH

Enhancing Nanoparticle Homing to Tumors
Erkki Ruoslahti, M.D., Ph.D.
Burnham Institute for Medical Research
University of California, Santa Barbara

Development of 'Smart' Nanoparticles for Cancer Therapy and Imaging
Joseph DeSimone, Ph.D.
University of North Carolina at Chapel Hill/
North Carolina State University
9:45 a.m. - 10:05 a.m. Break
10:05 a.m. - 11:45 a.m. Scientific Session I: Cancer Targeting Strategies (Grumman Auditorium)
Chair: Andrew Ellington, Ph.D.
University of Texas at Austin

Biomarker Discovery for Ovarian, Prostate, and Liver Cancers and Associated Network Perturbations
James Heath, Ph.D.
California Institute of Technology

Chlorotoxin-Bound Superparamagnetic Nanoparticles for Brain Tumor Diagnosis and Therapeutics
Miqin Zhang, Ph.D.
University of Washington

Development of Diagnostic and Therapeutic AntiTumor Aptamers
Andrew Ellington, Ph.D.
University of Texas at Austin

Nanotechnology Platform for Targeting Solid Tumors
Jan Schnitzer, M.D.
Sidney Kimmel Cancer Center
10:05 a.m. - 11:45 a.m. Scientific Session II: In Vivo Nano Delivery Platforms (Redbud)
Chair: Michael J. Cima, Ph.D.
Massachusetts Institute of Technology

Nanoscale Encasement and Targeted Delivery of Multifunctional Therapeutic Agents for Hematological Cancer and Solid Tumors
Thomas O'Halloran, Ph.D.
Northwestern University

Motherships for Nanodiagnostics and Nanotherapeutics
Michael Sailor, Ph.D.
University of California, San Diego

Acoustic Nanobeacons for Targeted Detection and Treatment of Tumor Angiogenesis
Michael Hughes, Ph.D.
Washington University in St. Louis

Implanted Superparamagnetic Sensors for Cancer Targets
Michael Cima, Ph.D.
Massachusetts Institute of Technology
11:45 a.m. - 1:00 p.m. Lunch (Trillium Room)
1:00 p.m. - 2:40 p.m. Scientific Session III: Nanotherapeutics (Grumman Auditorium)
Chair: Mansoor M. Amiji, Ph.D.
Northeastern University

Advances in Development of Novel Ternary-Structured Therapeutic Nanoparticles
Dong M. Shin, M.D.
Emory University

Selective Ablation of Metastatic Disease with Integrin αvβ3 Targeted Nanoparticle Drug Delivery
Eric Murphy, Ph.D.
University of California, San Diego

Engineering of Multi-Functional Nanoparticles for Therapeutic and Diagnostic Applications
Omid C. Farokhzad, M.D.
Brigham and Women’s Hospital/Harvard Medical School

Multifunctional Polymeric Nanoparticle Delivery Systems for Intracellular Ceramide Modulation as a Strategy to Overcome Tumor Drug Resistance
Mansoor M. Amiji, Ph.D.
Northeastern University
1:00 p.m. - 2:40 p.m. Scientific Session IV: Clinical Applications of Quantum Dots (Redbud)
Chair: Paras N. Prasad, Ph.D.
State University of New York at Buffalo
Quantum Dots and Biodegradable Nanoparticles for Cancer Imaging
Shuming Nie, Ph.D.
Emory University/Georgia Institute of Technology

Biological Modification of Quantum Dots for In Vivo Imaging
Xiaoyuan Chen, Ph.D.
Stanford University

Use of Conjugated Quantum Dots to Detect Cancer-Related Biomarkers
Roberd M. Bostick, M.D., M.P.H.
Emory University

Multifunctional Nanoparticles in Diagnosis and Therapy of Pancreatic Cancer
Paras N. Prasad, Ph.D.
State University of New York at Buffalo
2:40 p.m. - 4:00 p.m. Parallel Strategic Session of Alliance Coordinating and Governance Committee (all center PIs) (Redbud)
Moderator: Anna D. Barker, Ph.D.
National Cancer Institute, NIH
2:40 p.m. - 5:00 p.m. Poster Session (Atrium, Bellflower, Windflower, Willow)
5:30 p.m. - 10:00 p.m. Evening Event
Carolina Inn
John Sprunt Hill Ballroom
211 Pittsboro Street, Chapel Hill, NC

5:30 p.m.

 Buses depart for Carolina Inn.
Buses run consistently from 5:30 p.m. to 10:30 p.m.

Pickup and Dropoff:
Friday Center Lobby
Hotel Lobby, Courtyard by Marriott Chapel Hill
Hotel Lobby, Residents Inn Chapel Hill

6:00 p.m. - 6:40 p.m.

 Reception (Carolina Inn)

6:40 p.m. - 7:45 p.m.

 Dinner (Carolina Inn)

7:45 p.m. - 8:30 p.m.

 Keynote Presentation:
Nanoparticle Therapeutics: Concept to Clinic
Mark E. Davis, Ph.D.
Warren and Katharine Schlinger Professor of Chemical Engineering
California Institute of Technology
Founder, Insert Therapeutics, Inc.
Founder, Calando Pharmaceuticals, Inc.

10:30 p.m.

 Last bus leaves Carolina Inn for the hotels.
Thursday, October 18, 2007
7:00 a.m. - 5:00 p.m. Registration (Atrium)
7:00 a.m. - 8:00 a.m. Continental Breakfast (Atrium)
7:45 a.m. - 8:00 a.m. NCI Alliance Status Report (Grumman Auditorium)
Piotr Grodzinski, Ph.D.
National Cancer Institute, NIH
8:00 a.m. - 8:30 a.m. Poster Awards Presentation
Piotr Grodzinski, Ph.D.
National Cancer Institute, NIH

Rudy Juliano, Ph.D.
University of North Carolina at Chapel Hill
8:30 a.m. - 9:15 a.m. Working Group Reports
9:15 a.m. - 9:35 a.m. Break
9:35 a.m. - 12 noon Scientific Session V: Nanotechnology Devices for Early Diagnosis of Cancer (Grumman Auditorium)
Chair: Shan X. Wang, Ph.D.
Stanford University

Personalized Cancer Detection and Monitoring with Primer Approximation Multiplex PCR
Sadik Esener, Ph.D.
University of California, San Diego

Carbon Nanotube X-Ray for In Vivo Cancer Detection and Treatment
Otto Zhou, Ph.D.
University of North Carolina at Chapel Hill

Integrated System for Cancer Biomarker Detection
Scott Manalis, Ph.D.
Massachusetts Institute of Technology

Development of Barcode Assays for the Detection of Ovarian and Prostate Cancer
C. Shad Thaxton, M.D., Ph.D.
Northwestern University

Development of Microfluidics Integrated Nanoelectronic Sensors as a Diagnostic Tool for Pathologic Analysis of Cancer Tissues
Hsian-Rong Tseng, Ph.D.
University of California, Los Angeles

Magnetic Nanotechnology for Cancer Diagnostics and Therapy Monitoring
Shan X. Wang, Ph.D.
Stanford University
9:35 a.m. - 12 noon Scientific Session VI: Nanotechnology Contrast Agents for Medical Imaging (Redbud)
Chair: Kattesh V. Katti, Ph.D., M.Sc.Ed.
University of Missouri-Columbia

Neovascular-Directed MR Nanoparticles for Detection, Characterization, and Treatment of Cancer
Gregory M. Lanza, M.D., Ph.D.
Washington University in St. Louis

Developing Novel Hybrid Nanomaterials for Cancer-Specific Multimodal Imaging
Wenbin Lin, Ph.D.
University of North Carolina at Chapel Hill

Carbon Nanotubes for Biological Applications
Hongjie Dai, Ph.D.
Stanford University

Towards Long-Circulating Near-Infrared Fluorescence Nanoparticles
Chun Li, Ph.D.
University of Texas M.D. Anderson Cancer Center

TiΟ2 Nanocomposites for Targeted Treatment and Imaging of Prostate Cancer
Gayle Woloschak, Ph.D.
Northwestern University

Prostate Tumor Targeted Gold Nanoparticles for Molecular Imaging and Therapy
Kattesh V. Katti, Ph.D., M.Sc.Ed.
University of Missouri-Columbia
12 noon - 1:15 p.m. Lunch (Trillium Room)
1:15 p.m. - 3:10 p.m. Scientific Session VII: Controlling Cancer Metastasis with Nanotechnology Tools (Grumman Auditorium)
Chair: Leland W.K. Chung, Ph.D.
Emory University

Multimodal In Vivo Cell Imaging Nanoarrays
Stuart A. Solin, Ph.D., M.S.
Washington University in St. Louis

Nanopatterned Surfaces as Tools for the Quantitative Analysis of Tumor Cell Signaling and Migration
Muhammad N. Yousaf, Ph.D.
The University of North Carolina at Chapel Hill

Relative Expression Signatures for Cancer Diagnosis and Prognosis
Nathan D. Price, Ph.D.
University of Illinois at Urbana-Champaign

Deconstructing Directional Cell Motility in Metastasis Through Nanopatterning
Bartosz Grzybowski, Ph.D.
Northwestern University

Design and Use of Nanovectors to Image and Cotarget Lethal Prostate Cancer Bone Metastasis
Leland W.K. Chung, Ph.D.
Emory University
1:15 p.m. - 3:10 p.m. Scientific Session VIII: Nanomaterials: Toxicity, Characterization, and Data Sharing (Redbud)
Chair: Scott E. McNeil, Ph.D.
National Cancer Institute, NIH

MIT-Harvard CCNE Nanomaterial Toxicity Core
Sangeeta Bhatia, M.D., Ph.D.
Massachusetts Institute of Technology

Nanotechnology Informatics Resources at the Siteman CCNE
Nathan Baker, Ph.D.
Washington University in St. Louis

Role of the Bioinformatics and Biostatistics Resource Core in the Stanford CCNE
David Paik, Ph.D.
Stanford University

NCL Data: Trends in Biocompatibility and Toxicity
Scott E. McNeil, Ph.D.
National Cancer Institute, NIH
3:10 p.m. Poster Removal
(Please remove all posters by 3:30 p.m.)
3:10 p.m. - 3:30 p.m. Break
3:30 p.m.- 4:00 p.m. Plenary Talk (Grumman Auditorium)
Chair: Piotr Grodzinski, Ph.D.
National Cancer Institute, NIH

Nanotechnology - Path to the Clinic: Promises and Hurdles
James R. Baker, Jr., M.D.
University of Michigan
4:00 p.m. - 4:15 p.m. Closing Remarks/Adjournment